Does anyone suffer from a 'foggy' head which can cause a variety of concentration-related problems (some of them quite funny)? In this state I find it hard to maintain listening to what someone is saying, or maintaining a thread of thought in an essay or suchlike. Other things are extreme forgetfulness, like I've walked into a room to get something specific and left with something else; then remembered and gone back in, but AGAIN come out with something else. I get words muddled up too. One typical example is getting first letters mixed up. Yesterday for example, I said "Hox Funting" instead of... well you can guess. I also get the lower back pain, quivering hand/wrist muscles, tingling legs and extreme fatigue, but I find this 'foggy head' to be the most frustrating/enjoyable aspect of the syndrome.
Researchers are busy in their attempts to map out the full structure of the chromosome, including the Human Genome Database. Because of the small size of the 21st chromosome and its association with Down syndrome, it is the second-most heavily mapped human chromosome. Research is focusing on trying to identify genes and their effects when overexpressed.
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I am 19 years old and I was diagnosed with Gilberts syndrome about in 2000. I began to feel tired and weak after working over Christmas, my doctor told me after one set of blood tests but did another to confirm it wasn't any other liver disease. At first the symptoms were just constant tiredness, which I put down to working a lot of overtime. As I had more and more experiences of GS I noticed that I felt paranoid when I was out in public, as if people were watching me and because I was also feeling slightly depressed this made me very unhappy.
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In the early years it seemed to make no difference in a debilitating way as it seemed to be an inconvenience rather than an illness although my intolerance to alcohol was sometimes an experience I would rather forget (Bit of the never again syndrome). Things went downhill for me about eleven years ago after a viral infection. My intolerance of many drugs prescribed to try and resolve the problem only made matters worse. The long term effect of the viral infection left me with Fybromyalgia. I got terrible muscle aches all over. If I sat at the computer for even short periods my neck would ache and no amount of normal painkillers would even touch this sort of pain and discomfort.
The Epidemic of Mental Illness: Why
One of the more notable aspects of Down syndrome is the wide variety of features and characteristics of people with trisomy 21: There is a wide range of mental retardation and developmental delay noted among children with Down syndrome. Some babies are born with heart defects and others aren't. Some children have associated illnesses such as epilepsy, hypothyroidism or celiac disease, and others don't. The first possible reason is the difference in the genes that are triplicated. As I mentioned above, genes can come in different alternate forms, called "alleles." The effect of overexpression of genes may depend on which allele is present in the person with trisomy 21. The second reason that might be involved is called "penetrance." If one allele causes a condition to be present in some people but not others, that is called "variable penetrance," and that appears to be what happens with trisomy 21: the alleles don't do the same thing to every person who has it. Both reasons may be why there is such variation in children and adults with Down syndrome.
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I am a 32 year old English teacher. My physical problems concerning Gilbert Syndrome started after I came down with mono. It took several months for me to recover from it, but when I did I started experiencing IBS and other digestive problems… The IBS continued sporadically over the next five years. I tried to pinpoint a certain food that would trigger it, but nothing was consistent. This past summer was the climax of my Gilbert experience… I had difficulty digesting food. I was constipated, had stomach cramps/pain, felt nauseated every morning and during long periods of time when I didn't eat, and was extremely fatigued... This doctor told me the stomach pains must be stress related, and that I should find ways to decrease stress in my life. I thought this had some legitimacy, so I tried to change some things, but nothing improved. Then, this same doctor told me it might be gallbladder problems, and sent me to have some tests. No cysts, stones, or unusual developments were discovered. They then did tests of my digestive track, taking scans of food as it was processed. After two of these tests, and scoping down my throat, they found me to be perfectly healthy. We ruled out allergies, food poisoning, and dietary influences. I was normal in all accounts except my bilirubin count, which was more than double the normal amount... I have similar abdominal pain towards the right side just under my rib cage. The doctor thought it was gallbladder problems due to the location of the pain. However, those tests came back negative. After I eat, I also feel great discomfort, almost like I'm going to explode, even if I only eat a little bit. I find myself holding my stomach, or stretching to make room (as if I'd eaten a huge Thanksgiving dinner). Afterwards, the food rumbles in my stomach and causes short burps and mild acid reflux. I feel like I'm going to throw up, but I don't. It really is rather uncomfortable. The only source of comfort is to lay down flat on a couch.